In this work synthetic Y zeolite catalysts were modified by copper and sulfur loading and used for the Biginelli reaction to synthesize 3,4-dihydropyrimidine-2(1H)-on (DHPM). The Cu(II)-Y zeolites (CuHY) with different content of copper (CuHY2.5%
CuHY5.7%
CuHY8.6%) obtained via liquid phase ion exchange method while the sulfated Y zeolites (HYS) were prepared by impregnating zeolite Y in acid H2SO4. The characterization of the synthesized catalysts was carried out using the various physico-chemical methods such as the X-ray powder diffractometer (XRD) and X-ray fluorescence (XRF). All the characterization techniques used suggest and confirm the existence of the copper, sulferon the surface of Y-zeolite. The affecting conditions to the Biginelli reaction in synthesis of 3,4-dihydropyrimidine-2(1H)-on (DHPM) compounds using catalysts have been studied. The suitable conditions for the reaction were found as catalyst CuHY8,6%
toluene as a solvent
reaction time of 72 hours with maximum efficiency. The yield of the reaction increased proportionally to the content of Cu2+ in a zeolite (CuHY8,6%>
CuHY5,7%>
CuHY2,5%>
HYS) and higher than that of the reaction using zeolite sulfate Y. Eight DHPM derivatives were synthesized with 35-51% yield, of which two new compounds were found. Activity of reusable catalyst was the same fresh catalyst. The structures of the reaction products were confirmed by IR, NMR and MS methods