This paper presents results of research on preparation of TiO2/SiO2 photocatalytic material applying for treatment of wastewater containing 2,4,6-Trinitrotoluen. Results of synthesizing TiO2/SiO2 photocatalysis by sol-gel method in water - organic solvent with a 1:1 molar ratio show the apperance of grain in the form of anatase TiO2 grip on SiO2 with nano-sized of 5 - 20 nm when sample calcined at 500oC. Studyingon the ability to apply new materials for wastewater treatment containing 2,4,6-Trinitrotoluen shows that TiO2/SiO2 is 6 g/L for the largest performance degradation reaching 65.6%. At the same time the processof TNT decomposition occurs in neutral and alkaline environments. In addition, the reaction temperaturedoes not affect the performance of the decomposition reaction of TNT.