Dihydroquercetin (DHQ), also known as taxifolin, is a flavonoid and commonly found in many plants. DHQ has been documented to have powerful antioxidant activity and many beneficial properties for human health. However, its low solubility and bioavailability are major obstacles to biomedical applications. In the present study, a DHQ nanoemulsion formulation was prepared by self nanoemulsifying drug delivery system (SNEDDS) technique to overcome these disadvantages. The obtained nanoemulsion system was also evaluated for its microscopic properties, and in vitroantioxidant activity against artificial radical ABTS*(2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), protect cells. Measurement results showed that the DHQ nanoemulsion was successfully synthesized with typical mean droplet sizes from 9 to 11 nm. The in vitro experiments on antioxidant activities against ABTS radical indicated that both DHQ unencapsulated form and its nanoemulsion effectively inhibit the development of ABTS*free radical, however, DHQ nanoemulsion inhibits better than the control Trolox with the IC50 values (µg/ml) of DHQ unencapsulated form, its nanoemulsion and Trolox are respectively 474,2
238,5
331. The results of this study provide useful information on the potential use of DHQ nanoemulsion as a promising agent in the tumor treatment caused by free radicals and the development of a drug for the beings’aims.