Propolis is a beehive product containing plant resin and beeswax, that is used for protecting the beehive from disease pathogen. Propolis possesses wide range of biological and pharmacological properties. The chemical constituents of propolis are quite diverse and propolis chemistry depends on the geographical origin, plant species, and bee species. In our investigation, four xanthones including cochinchinone A (1), cratoxylumxanthone B (2), cochinchinone K (3) and γ-mangostin (4) were isolated from stingless bee Tetrigona irridipennis propolis collected in Binhdinh province. Their chemical structures were elucidated by NMR, MS spectral analysis and comparison with reported literatures. Our chemical study suggested that Cratoxylum cochinchinense is one of plant sources for propolis of stingless bee Tetrigona irridipennis in Binhdinh province