HOẠT TÍNH CHỐNG ĐÁI THÁO ĐƯỜNG VÀ CHỐNG UNG THƯ CỦA MỘT SỐ HỢP CHẤT LAI COUMARIN-PYRIMIDINE

• Tác giả: Thúy Vân Đinh, Ngọc Toàn Dương, Đình Thành Nguyễn
• Ngôn ngữ: vie
• Thông tin xuất bản: Tạp chí Phân tích Hóa, Lý và Sinh học, 2023
• Mô tả vật lý: tr.170
• Bộ sưu tập: Metadata
• ID: 340948

Tóm tắt

A series coumarin-pyrimidine hybrid compounds were synthesized by condensation reaction of α,βunsaturated ketone of 6-acetyl-5-hydroxy-4-methylcoumarin with guanidine. The yields of obtained hybrid compounds were about 42-62%. Their antidiabetic and anticancer activities were scanned by the standard methods. These compounds exhibited low toxicity to two cancer cell lines KB and HepG2, but have remarkably inhibitory activity against diabetes enzymes. All synthesized hybrid compoundswere examined for in vitro α-amylase (with IC50 values in the range of 102.32 ± 1.15 μM to 249.52 ± 1.14 μM) and α- glucosidase (with IC50 values in the range of 52.16 ± 1.12 μM to 184.52 ± 1.15 μM) inhibitory activity.