Sự lưu hành của virus lở mồm long móng và hàm lượng kháng thể của gia sức sau tiêm phòng vacxin type 0 (>GPD50) tại Tỉnh Tiền Giang

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Tác giả: Chi Mai Đường, Thanh Phương Nguyễn, Văn Dung Nguyễn, Văn Vang Phạm, Minh Hải Tăng, Quốc Hiếu Thái

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2023

Mô tả vật lý: tr.20

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ID: 340997

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Đề tài được thực hiện nhằm xác định sự lưu hành của virus lở mồm long móng (LMLM) trên đàn gia súc tại tỉnh Tiền Giang từ năm 2016 đến năm 2020 và theo dõi lượng kháng thể của bò, heo sau tiêm phòng vacxin Aftopor đơn giá, type O (>
6PD50). Trong phạm vi nghiên cứu này, virus LMLM lưu hành ở Tiền Giang có liên quan đến type A và O
trong đó type A chỉ xảy ra trên bò với dòng ASIA/Sea-97, type O xảy ratrên bò và heo. Ở bò có 2 dòng (O/ME-SA/PanAsia và O/ME-SA/Ind-2001e) và ở heo có 4 dòng (O/Cathay, O/ME-SA/PanAsia, O/ME-SA/Ind-2001e và O/SEA/Mya-98). Kết quả xét nghiệm kháng thể bằng kỹ thuật ELISA và trung hòa virus trên tế bào (VNT) cho thấy đáp ứng miễn dịch kháng thể sau khi tiêm vacxin LMLM type O (>
6PD50) ở heo thịt sau tiêm 2 mũi đạt 100%
heo nái tiêm 1 mũi đạt 90% và bò tiêm 1 mũiđạt 100%. Trong đó, trên heo thịt, heo nái và bò đều đạt tỷ lệ bảo hộ cao (>
93%) đối với virus LMLM thực địa dòng O/ME-SA/Ind-2001e. Kết quả này cho thấy vacxin Aftopor đơn giá type O (>
6PD50) đạt hiệu quả cao khi sử dụng phòng chống bệnh LMLM type O cho bò và heo trên địa bàn tỉnh Tiền Giang.The study was conducted to determine the circulation of foot-and-mouth disease virus (FMDV) in the pigs and cattle in Tien Giang province from 2016 to 2020 and to monitor antibody levels of these animals after injection with Aftopor monovalent O 6PD50 vaccine. The studied result showed that FMDV in Tien Giang was associated with serotypes A and O
in which, serotype A was only detected in cattle (ASIA/Sea-97), serotype O was detected in both cattle and pigs. Among serotype O, we found 2 viral lineages in cattle (O/ME-SA/PanAsia and O/ME-SA/Ind-2001e) and 4 viral lineages in pigs (O/Cathay, O/ME-SA/PanAsia, O/ME-SA/Ind-2001e and O/SEA/Mya-98). ELISA and virus neutralization on animal cells showed that 2-doses-injected pigs
1-dose-injected sows and cows with aftopor monovalent O 6PD50 vaccine acquired 100%, 90% and 100% of seropositive samples with anti-FMDV antibodies, respectively. In the pigs, sows and cows, all protection rates were achieved higher than 93% for the lineage Ind-2001e, suggesting that this vaccine is highly effective to use for preventing FMDV in cattle and pigs in Tien Giang province.

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