Khảo sát đặc điểm mô bệnh học và biểu hiện phân tử của một số loại u khối mô mềm trên chó

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Tác giả: Diệu Linh Đinh, Thành Luân Nguyễn, Thị Hải Hà Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2023

Mô tả vật lý: tr.65

Bộ sưu tập: Metadata

ID: 341049

Thêm vào giỏ Liên kết toàn văn

Tái phát cục bộ sau khi phẫu thuật cắt bỏ khối u mô mềm (STS) là lý do thông thường dẫn đến thất bại trong điều trị và quản lý STS, và có thể xảy ra ở 7 - 75% thú bệnh, tái phát liên tục có liên quan đến việc giảm khả năng sống sót chung của chó. Trong nghiên cứu này, tỷ lệ chó có khối u ghi nhậnđược trong nghiên cứu là 1,5%. Kết quả phân tích đặc điểm hình thái mô bệnh học của khối u vành tai trên chó Chow Chow cho thấy sự tăng sinh mạnh của các tế bào hình thoi, có sự thay đổi về kích thước, hình dạng, sự cụm lại, và có sự xuất hiện của các bạch cầu xâm nhập xung quanh mạch máu.Tương tự, kết quả phân tích hóa mô khối u âm đạo trên chó French Bulldog cho thấy mật độ tế bào khối u bình thường, bao gồm các tế bào sợi trưởng thành, hình thành nhiều sợi collagen và không có sự tăng sinh mạnh và dữ dội của các tế bào. Đặc biệt, phân tích sự biểu hiện của một số loại markerphân tử từ các sinh thiết từ khối u mô bào ở vú chó Husky cho thấy các tế bào biểu hiện mạnh với vimentin (68,1%) có liên quan đến đặc điểm di căn ác tính. Các tế bào u di căn tên Husky có thể làm thay đổi các chỉ tiêu sinh hóa máu đi kèm với tình trạng nhiễm trùng huyết nên chó không đủ điềukiện để tiến hành phẫu thuật. Nhìn chung, việc kiểm tra mô học và đánh giá mức độ biểu hiện của các markers có thể giúp xác định tình trạng nguy hiểm của các khối u trên chó và cần được mở rộng đánh giá trong các liệu pháp can thiệp và hạn chế tái phát cục bộ sau khi phẫu thuật cắt bỏ.Treatment failure in canine soft tissue tumors, a locally invasive mesenchymal neoplasm may occur in between 7 and 75% of patients, with recurrence consistently associated with reduced overall survival for the dog. In this study, the percentage of tissue sarcoma in the dog was 1.5%. Histopathological analysis characteristics of the ear lobe tumors in Chow Chow showed a strong proliferation of rhabdoid cells, changes in size, shape, clustering, and presence of leukocytes infiltrating around blood vessels. Also, histopathological study of vaginal tumors in French Bulldog showed normal tumor cell density, including mature fibroblasts, formation of many collagen fibers and no strong proliferation and ferocity of cells. In particular, immuno-histopathological analysis of biopsies sample from breast tumor of Husky showed an overexpressing of vimentin in cells (68.1%) which associated with malignant metastasis status. The metastatic tumor cells in Husky might change the blood biochemical parameters together with sepsis, thus the dog was not eligible for surgery. In general, histological examination and expression levels of markers can help determine the malignant status of tumors in dogs and should be included medical examination to limit local recurrence following surgical resection.

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