Khảo sát độc tính bán trường diễn đường uống trên chuột nhắt trắng của cao chiết lá Sa kê (Artocarpus altilis (Parkinson) Fosberg, Moraceae)

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Tác giả: Thị Mỹ Duyên Dương, Thị Ngọc Linh Dương, Anh Khang Lê, Lâm Hoàng Nguyễn, Thị Thu Hiền Nguyễn, Thị Thùy Trang Nguyễn, Hiền Nhật Võ, Thị Thu Hà Võ, Vũ

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2023

Mô tả vật lý: tr.81

Bộ sưu tập: Metadata

ID: 341562

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Many studies have demonstrated the effects of breadfruit leaf extract such as anti-inflammatory, antioxidant and immunosuppressive. The aim of this work was to study on the semi-chronic toxicity of oral administration of the extract of Artocarpus altilis (Parkinson) Fosberg, Moraceae in mice to assess its safety. The hot water extraction method was conducted to obtain the extract. Repeated dose 90-day − oral semi-chronic toxicity study in mice was investigated based on “Guidelines for preclinical and clinical trials of traditional medicines and herbal medicines” of Ministry of Health and OECD 408 guidance. At the doses of 250 mg/kg and 500 mg/kg (breadfruit extract/ mouse body weight), mice were healthy and their weight increased weekly. The indices of RBC, WBC, platelets, liver enzymes (ALT, AST), serum urea and creatinine levels did not significantly change. However, at the higher dose (500 mg/kg) there were hepatitis and nephritis in histology on experimental mice after 90 days. The breadfruit extract did not significantly change general physiology, complete blood count, liver and kidney function of mice. However, prolonging overdose is not recommended. The results of this study provide information on the safety of breadfruit extract. This would be useful for further study in pharmacology.Nhiều nghiên cứu đã chứng minh tác dụng của lá Sa kê như kháng viêm, chống oxi hóa và ức chế miễn dịch. Nghiên cứu được thực hiện với mục tiêu khảo sát độc tính bán trường diễn nhằm cung cấp cơ sở khoa học về tính an toàn của cao chiết lá Sa kê. Độc tính bán trường diễn thực hiện theo “Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu”của Bộ Y tế và OECD 408. Kết quả cho thấy, ở liều 250 mg/kg và 500 mg/kg cao chiết lá Sa kê, chuột khỏe mạnh, tăng cân đều. Các chỉ số hồng cầu, bạch cầu, tiểu cầu, hoạt tính men gan AST, ALT, ure và creatinin của chuột thay đổi không đáng kể. Tuy nhiên về mặt vi phẫu có hiện tượng viêm gan và viêm thận khi sử dụng liều cao sau 90 ngày thử nghiệm. Cao chiết lá Sa kê không làm thay đổi đáng kể lên thể trạng chung, công thức máu, chức năng gan, thận của chuột. Tuy nhiên nên thận trọng khi dùng liều cao kéo dài. Nghiên cứu này có thể làm cơ sở khoa học về tính an toàn của cao chiết tạo tiền đề cho các nghiên cứu tác dụng dược lí về sau.

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