Bất thường tim mạch ở thai hội chứng DiGeorge phát hiện qua siêu âm tại Bệnh viện Phụ sản Trung Ương

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Tác giả: Thị Thủy Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học Sức khỏe, 2024

Mô tả vật lý: tr.92

Bộ sưu tập: Báo, Tạp chí

ID: 341926

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Mục tiêu nghiên cứu: Mô tả đặc điểm nhóm thai phụ mang thai hội chứng DiGeorge (DiGeorge Syndrome – DGS) và các bất thường tim mạch ở thai hội chứng DiGeorge phát hiện qua siêu âm. Phương pháp nghiên cứu: Mô tả chùm ca bệnh. Kết quả: 23/31 thai phụ mang thai DGS có chỉ định chọc ối nằm trong độ tuổi dưới 35, cao gần gấp 3 lần so với nhóm thai phụ nằm trong độ tuổi trên 35 (8 thai phụ tương ứng với 25,8%). Các bất thường tim mạch gặp ở thai hội chứng DiGeorge với tỷ lệ chung là 64,5%. Trong đó tứ chứng Fallot gặp phổ biến nhất với 15 ca (48,4%)
theo sau là thông liên thất đơn độc (4 ca với 12,9%) và bất thường mạch (1 ca với 3,2%). Thời điểm phát hiện bất thường tứ chứng Fallot ở thai hội chứng DiGeorge là khá muộn trung bình ở mốc 20-24 tuần thai (9 trường hợp – 60%). Với 4 trường hợp thông liên thất, thai được phát hiện sớm nhất khi siêu âm 17 tuần 6 ngày, muộn nhất là 24 tuần 4 ngày. Bất thường mạch được phát hiện ở siêu âm thai 22 tuần với các biểu hiện : hẹp đường ra thất trái, giãn quai động mạch chủ. Kết luận: Không có mối liên quan giữa tăng tỷ lệ thai hội chứng DiGeorge theo tuổi mẹ. Bất thường tim mạch là bất thường phổ biến ở thai hội chứng DiGeorge với 64,5% (20/31 trường hợp), trong đó tứ chứng Fallot đặc hiệu nhất cho DGS với 15 trường hợp chiếm 48,4%, theo sau là 4 trường hợp thông liên thất (12,9%), 1 trường hợp bất thường mạch chiếm 3,2%. Thời điểm phát hiện bất thường tim mạch khá muộn thường tập trung ở tuần 20 -22.Objectives: Describe the characteristics of pregnant women with DiGeorge syndrome (DGS). Describe the cardiovascular abnormalities in DiGeorge syndrome detected by ultrasound. Research method: Descriptive research of a series diseases. Results: 23/31 pregnant women with DGS who indicated for amniocentesis were under the age of 35, nearly 3 times higher than the group of pregnant women over the age of 35 (8 pregnant women corresponded to 25.8%). Statistics of cardiovascular abnormalities seen in DiGeorge syndrome with the overall rate is 64.5%. In which tetralogy of Fallot was the most common with 15 cases, accounting for 48.4%
followed ventricular septal defect (4 cases with 12.9%) and vascular abnormalities (1 case with 3.2%). The time of abnormal detection of tetralogy of Fallot in fetus with DiGeorge syndrome is quite late, most cases are detected at 20-24 weeks of gestation (9 cases - 60%). With 4 cases of ventricular septal defect, the fetus was detected at the earliest at 17 weeks and 6 days of ultrasound, 24 weeks and 4 days at the latest. Vascular abnormalities were detected at 22 weeks of pregnancy (left ventricular outflow tract stenosis), aortic arch dilatation. Conclusion: There is no relationship between increased incidence of DiGeorge syndrome pregnancy according to maternal age. Cardiovascular abnormalities are common abnormalities in DiGeorge syndrome with 64.5% (20/31 cases), in which tetralogy of Fallot is most specific for DGS with 15 cases accounting for 48.4%, followed by tetralogy of Fallot. 4 cases of ventricular septal defect (12.9%), 1 case of abnormal pulse accounted for 3.2%. The time to detect cardiovascular abnormalities is quite late, usually at weeks 20-22.

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