Giá trị xét nghiệm Gene Xpert MTB/RIF đàm trong chẩn đoán lao phổi mới AFB(-)

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Tác giả: Thị Hồng Cao, Văn Long Hoàng, Thị Bình Nguyên Nguyễn, Thanh Bính Phan, Thị Phương Phan

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học lâm sàng Bệnh viện Trung ương Huế, 2023

Mô tả vật lý: tr.58-61

Bộ sưu tập: Metadata

ID: 343043

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Đặt vấn đề: Xét nghiệm soi AFB đàm trực tiếp có độ nhạy không cao, dễ bỏ sót lao phổi AFB(-). Việt Nam đã triển khai XN Gene Xpert MTB/RIF như một kỹ thuật chẩn đoán nhanh bệnh lao. Đề tài nhằm đánh giá tỉ lệ lao phổi mới AFB(-), khảo sát và so sánh một số đặc điểm với lao phổi mới AFB(+)
Xác định độ nhạy của XN Gene Xpert MTB/RIF trong chẩn đoán lao phổi mới AFB(-). Đối tượng, phương pháp: Đối tượng là 328 bệnh nhân lao phổi mới gồm 202 AFB(-) và 126 AFB(+), phương pháp mô tả cắt ngang. Kết quả: Tỉ lệ lao phổi mới AFB(-) chiếm 61,58%. So sánh với lao phổi mới AFB(+): Tỉ lệ vào các khoa khác của lao phổi mới AFB(-) cao hơn (20,09%, vs 11,11%: p <
0,01), tổn thương có hang thấp hơn (30,20% vs 41,27%: p <
0,05), tổn thương phổi độ I cao hơn (32,67% vs 20,63%: p <
0,05). Độ nhạy của XN Gene Xpert MTB/RIF đàm trong chẩn đoán lao phổi mới AFB(-) là 72,28%. Kết luận: Độ nhạy của XN Gene Xpert MTB/RIF đàm trong chẩn đoán lao phổi mới AFB(-) là 72,28%. Từ khóa: Lao phổi mới AFB(-), Gene Xpert MTB/RIF. ABSTRACT Value of GENE XPERT MTB/RIF sputum test in the diagnosis of new Pulmonary Tb AFB(-) Phan Thanh Binh1, Nguyen Thi Binh Nguyen2, Phan Thi Phuong1, Hoang Van Long1, Cao Thi Hong1 Background: Direct sputum AFB test has low sensitivity, easy to miss AFB (-) pulmonary tuberculosis. Vietnam has deployed the Gene Xpert MTB/RIF test as a rapid diagnostic technique for tuberculosis. To evaluate the rate of new pulmonary TB AFB(-), survey and compare some characteristics with new pulmonary TB AFB(+)
Determination of the sensitivity of Gene Xpert MTB/RIF test in the diagnosis of new pulmonary TB AFB(-). Methods: Subjects were 328 new pulmonary tuberculosis patients, including 202 AFB(-) and 126 AFB(+), descriptive cross-sectional method. Results: The rate of new pulmonary tuberculosis AFB(-) accounted for 61.58%. Compared with new pulmonary TB AFB(+): The rate of admission to other departments of new pulmonary TB AFB(-) is higher (20.09%, vs 11.11%: p <
0.01), lesions with cavernous lesions lower (30.20% vs 41.27%: p <
0.05), higher grade I lung injury (32.67% vs 20.63%: p <
0.05). The sensitivity of Gene Xpert MTB/RIF sputum test in the diagnosis of new pulmonary TB AFB(-) is 72.28%. Conclusions: The sensitivity of Gene Xpert MTB/RIF sputum test in the diagnosis of new pulmonary TB AFB(-) is 72.28%.

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