Orthodontics is one of the increasingly popular dental specialties. With the driving force in technology and the development of materials, nowadays, straightening options is more predictable with clear aligner, it helps to improve the problems of malocclusion more possibly and more comfortably. It is known as a highly aesthetic orthodontic appliance, which is near-invisible, enhances oral hygiene as well as comfort during treatment. Invisalign is one of the pioneers in clear aligners, that’s why clear aligners is warmly welcomed all over the world and particularly in Vietnam. In this article, we report two cases of comprehensive treatment with clear aligner from Invisalign within 18 months, under the support of artificial intelligence to plan tooth movement through Clincheck© software. The aim is to present the efficacy of the latest orthodontic therapy, and to offer patients more treatment options in correcting various types of malocclusion.