Bước đầu nghiên cứu ứng dụng phương pháp sắc ký lỏng ghép nối khối phổ tứ cực thời gian bay (LC-QTOF-MS) để giám sát tồn dư hóa chất bảo vệ thực vật trong rau củ quả

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Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Kiểm nghiệm và An toàn thực phẩm, 2023

Mô tả vật lý: tr.325-342

Bộ sưu tập: Metadata

ID: 345298

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Currently, there are thousands of plant protection chemicals being allowed for use in agriculture. Abuse or improper use of pesticides lead to increase residues in products, exceeding the maximum residue limit according to the regulations. Therefore, the need for developing methods, which can monitor, detect, and identify many pesticides simultaneously is necessary. The liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) method has advantage of being able to simultaneously quantify and screen many compounds at once, are being a trend in analytical techniques for analyzing and screening pesticide residues in foods. In this study, the LC-QTOF-MS method was used to quantify 186 pesticides in fruit and vegetable samples. The limit of detection (LOD) for all compounds is 3.0 µg/kg. The recovery is in the ranged of 74.4 -118%, relative standard deviation (RSD) <
20%. At the same time, the method was initial researched for nontarget screening by reprocessing previously acquired data without re-injection of the samples. The list of pesticides can be screening, which are up to 500 chemicals, by comparison results with the available high resolution mass spectral library. The screening detection limit of the method (SDL) is 100 µg/kg. The method has been applied to quantify 186 pesticides, and nontarget screening analyse in 160 fruit and vegetable samples in the first 06 months of 2023.Hiện nay, có hàng nghìn hóa chất bảo vệ thực vật (HCBVTV) đang được cho phép sử dụng trong nông nghiệp. Việc lạm dụng hoặc sử dụng HCBVTV không đúng cách sẽ dẫn đến tồn dư trong các sản phẩm tăng lên, vượt quá giá trị giới hạn dư lượng tối đa (MRL) theo qui định. Do đó, việc xây dựng các phương pháp phân tích có thể giám sát, phát hiện và xác định đồng thời nhiều HCBVTV là nhu cầu cần thiết. Phương pháp sắc ký lỏng ghép nối khối phổ tứ cực thời gian bay (LC-QTOF-MS) với ưu điểm có thể định lượng và sàng lọc đồng thời nhiều hợp chất trong cùng một lần phân tích, đang là một trong hướng phát triển để giám sát nhiều HCBVTV trên thế giới. Trong nghiên cứu này, phương pháp LCQTOF-MS đã được sử dụng để định lượng 186 HCBVTV trong mẫu rau củ quả. Giới hạn phát hiện của phương pháp (LOD) là 3,0 µg/kg. Hiệu suất thu hồi của phương pháp dao động từ 74,4-118%, độ lặp lại RSD <
20%. Đồng thời, phương pháp bước đầu được nghiên cứu để sàng lọc tìm kiếm các chất nghi ngờ có trong mẫu lên tới 500 hóa chất, dựa trên kết quả so sánh với thư viện phổ phân giải cao có sẵn kèm theo thiết bị. Giới hạn phát hiện sàng lọc của phương pháp (SDL) là 100 µg/kg. Phương pháp đã được áp dụng để định lượng 186 HCBVTV, đồng thời sàng lọc tìm kiếm HCBVTV nghi ngờ trong 160 mẫu rau củ quả, trong 06 tháng đầu năm 2023.

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