Khả năng chống oxy hóa và kháng viêm của chiết xuất cồn và nước từ thân cành cù đèn (Croton oblongifolius Roxb.)

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Tác giả: Phạm Thị Hải Hà, Ngô Hoàng Long, Từ Khởi Thành, Trúc Châu Thị Nhã

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023

Mô tả vật lý: tr.27-37

Bộ sưu tập: Metadata

ID: 345655

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Giới thiệu: Cù đèn (Croton oblongifolius Roxb.) thuộc họ Euphorbiaceae, là cây dược liệu phân bố ở nhiều nước trong vùng Đông Nam Á trong đó có Việt Nam. Cù đèn được tìm thấy nhiều trong các bài thuốc dân tộc để hỗ trợ, chữa trị các bệnh viêm nhiễm khác nhau. Vật liệu và phương pháp: Thân cành Cù đèn được chiết xuất bằng các phương pháp hồi lưu với các dung môi khác nhau. Khả năng bắt gốc tự do DPPH được thực hiện để khảo sát hoạt tính chống oxy hóa. Ngoài ra, các thí nghiệm khảo sát khả năng kháng viêm được thực hiện qua mô hình động vật in vivo bằng phương pháp độc tính cấp tính đường uống và cảm ứng carrageenan. Kết quả: Dịch chiết cồn Cù đèn thể hiện hoạt tính chống oxy hóa khả quan với IC50 đạt được là 189.25 µg/ml. Kết quả độc tính cấp tính cho thấy Dmax của chiết xuất ACO và ECO lần lượt là 21 và 23.93 g/kg trọng lượng chuột và không có triệu chứng bất thường nào xảy ra ở động vật. Ngoài ra, dịch chiết cồn (0.24 g/kg) thể hiện khả năng kháng viêm mạnh khi so sánh cùng thuốc đối chiếu Celecoxib (25 mg/kg). Kết luận: Những kết quả thu được đóng góp cho nền tảng nghiên cứu trong tương lai về các đặc tính kháng viêm, cũng như việc xác định cơ chế điều trị bệnh.Introduction: Croton oblongifolius Roxb. is a member of the Euphorbiaceae family that grows naturally or in cultivation in a variety of locations, including Vietnam. This plant is still used in traditional medicine to treat diarrhea, edema, and other inflammatory diseases. Materials and methods: The stem is extracted by boiling it in a water bath with distinct solvents under reflux. The DPPH assay is performed to evaluate antioxidant activity. Moreover, an acute toxicity test is performed on 10 male Swiss albino strain mice, divided into two groups, and given different extracts of C. oblongifolious. The in vivo anti-inflammatory experiment is applied to the paws of mice utilizing the carrageenan induction method. Results: The results demonstrate that the absolute ethanol extract exhibits significant in vitro antioxidant activity with an IC50 of 189.25 µg/ml in the DPPH assay. The acute toxicity results show that the Dmax of ACO and ECO extracts is 21 g/kg and 23.93 g/kg of mouse weight, respectively, with no abnormalities in any of the animals. Furthermore, the ethanol extract (0.24 g/kg) exhibits potent inhibition of inflammation compared to celecoxib (25 mg/kg). Conclusions: The findings of this study establish the groundwork for future research into the mechanism of anti-inflammatory properties, as well as the identification of specific pharmacological routes.

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