STEM is a common abbreviation for four closely connected areas of study: Science (S), Technology (T), Engineering (E) and Mathematics (M). The fields are often associated due to the similarities that they share both in theory and practice. STEM education is not a new teaching orientation, it is just a form of integrated teaching in an interdisciplinary approach (at least 2 out of 4 areas of Science, Technology, Engineering and Mathematics) has been done for a long time in the world as well as in Vietnam. The difference of STEM education is mainly reflected in the use of scientific, engineering, technological and mathematical knowledge to create products or models for real life. This article is interested in teaching Multivariable Linear Regression to develop STEM skills for university students.