CÁC HỢP CHẤT FLAVONE GLYCOSIDE PHÂN LẬP TỪ LÁ CÂY LÃNH CÔNG BẮC (FISSISTIGMA TONKINENSIS)

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Tác giả: Xuân Thắng Đàm, Hà Thanh Nguyễn, Thị Kim An Nguyễn, Thế Chính Phạm, Thị Thắm Phạm, Thị Thu Giang Phạm

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học & Công nghệ - Trường Đại học Công nghiệp Hà Nội, 2023

Mô tả vật lý: tr.112

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ID: 346879

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Fissitigma tonkinensis is a small woody species. According to traditional medicine, the root bark of this species is often used to bundle broken bones. This species is distributed in Quang Ninh, often growing naturally in the margins of secondary forests [1]. So far, there have been no announcements on the chemical composition and biological activity of this species. In this paper, phytochemical constituents of the methanol extract of the leaves of the F. tonkinensis were studied. Six flavone glycoside compounds were isolated by the combination of various chromatographic methods. The chemical structures of these compounds were identified to be kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-galactopyranoside (1), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (2), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3), isoquercitrin (4), kaempferol 3-O-β-D-glucopyranoside (5), quercetin (6) by analyzing one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance spectroscopy (NMR) in comparison with the corresponding data reported in the previous literature.Loài Fissitigma tonkinensis (lãnh công bắc hay cách thư Bắc bộ) là một loài thân gỗ nhỏ. Theo y học cổ truyền, phần vỏ rễ loài này thường được dùng để chữa viêm khớp dạng thấp, gãy xương và đau khớp. Cây lãnh công bắc được phân bố ở các tỉnh miền núi phía Bắc như Thái Nguyên, Lai Châu, Hà Giang, Phú Thọ, Quảng Ninh [1]. Cho đến nay, trên thế giới và trong nước vẫn chưa có công bố nào về thành phần hóa học cũng như hoạt tính sinh học của loài này. Trong nghiên cứu này, chúng tôi tập trung nghiên cứu thành phần hóa học của dịch chiết metanol của lá cây. Từ cặn chiết methanol của lá loài lãnh công bắc, 6 hợp chất khung flavone glycoside đã được phân lập. Cấu trúc của chúng được xác định là: kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-galactopyranoside (1), kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (2), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3), Isoquercitrin (4), kaempferol 3-O-β-D-glucopyranoside (5), quercitrin (6) bằng phổ cộng hưởng từ hạt nhân một chiều (1D NMR) và hai chiều (2D NMR), so sánh với dữ liệu được công bố.

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