HIỆU QUẢ CỦA CHẤT KHỬ NHIỄM DA DCBRN-01VN ĐỐI VỚI ĐỘNG VẬT TIẾP XÚC VỚI CHẤT 2-CHLOROETHYL ETHYL SULFIDE

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Tác giả: Ba Cuong Nguyen, Thanh Vinh Nguyen, Ngoc Doan Vu, Quang Hung Vu

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Science and Technique: Section on Physics and Chemical Engineering, 2023

Mô tả vật lý: tr.85

Bộ sưu tập: Metadata

ID: 347078

Thêm vào giỏ Liên kết toàn văn

Các tác nhân chiến tranh hóa học là một mối đe dọa thực sự và việc khử nhiễm cho nạn nhân là mối quan tâm chính khi xảy ra phơi nhiễm hàng loạt. Nghiên cứu tiến hành đánh giá hiệu quả chất khử nhiễm da DCBRN-01VN trên cơ sở hợp chất oxime KBDO đối với CEES (2-chloroethyl ethyl sulfide). Phương pháp phân tích HPLC được sử dụng để xác định nồng độ sau khử nhiễm trong các thử nghiệm in vitro và in vivo, sau đó kiểm tra các thông số sinh hóa, huyết học trên chuột. Kết quả thử nghiệm cho thấy DCBRN-01VN có hiệu quả khử nhiễm CEES cao,in vitro: với tỉ lệ CEES : chất khử nhiễm là tỉ lệ 1:20 trong thời gian 10 phút đạt 55,04%, với tỉ lệ 1:10 trong 20 phút đạt 55,95%, 30 phút đạt 82,93%, 60 đạt gần 100%
in vivo với tỉ lệ 1:15 trong 20 phút đạt gần 100%. Kết quả kiểm tra sinh hóa và huyết học không có thấy sự khác biệt giữa nhóm chứng âm và 2 nhóm thử nghiệm (có khử nhiễm và không khử nhiễm) P(2-1) >
0,05
P(3-1) >
0,05. Phân tích mô bệnh học cho thấy khử nhiễm cũng làm giảm tổn thương do CEES gây ra.Chemical warfare agents are an actual threat and decontamination for victims is a main concern when mass exposure occurs. The study evaluated the effectiveness of the skin decontamination agent DCBRN-01VN based on the oxime compound KBDO for CEES (2-chloroethyl ethyl sulfide). HPLC analysis method was used to determine the temperature after decontamination in vitro and in vivo tests and then to check biochemical and hematological indicators in rats. The test results show that DCBRN-01VN has a high efficiency of CEES decontamination, in vitro: with the ratio of CEES: decontaminant 1:20 in 10 minutes reaching 55.04%, with the ratio 1:10 in 20 minutes reached 55.95%, in 30 minutes reached 82.93%, in 60 minutes reached nearly 100%
in vivo test with a ratio of 1:15 in 20 minutes reached almost 100%. Results of biochemical and hematological examination showed no difference between the negative control group and two experimental groups (with decontamination and without decontamination) P(2-1) >
0.05
P(3-1) >
0.05. Histopathological analysis showed that decontamination also reduced damage caused by CEES.

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