Artocarpus integer has been used as traditional medicine in Asian countries. This plant is common in Southern provinces of Vietnam, such as Binh Phuoc, Gia Lai, and Dong Nai. Investigation of the phytochemical of fruits of Artocarpus integer showed that flavonoid derivatives exhibited anti-inflammatory, antioxidant, antibacterial properties, and enzyme α-glucosidase inhibitions. This study isolated some compounds from ethyl acetate extract of leaves of Artocarpus integer. Four compounds including catechin (1), epi-catechin (2), (2S)-8-(3''-methylbut-2''-enyl)-7,3',4'-trihydroxyflavanone (3), and (2S)-liquiritigenin (4) were isolated from the ethyl acetate extract of Artocarpus integer leaves collected in Binh Phuoc Province. Their chemical structures were elucidated by comparing their spectroscopic data with reported data in the literature