The management of information technology application in teaching at the Mien Đong College, Bien Hoa city, in Đong Nai province has neither been implemented regularly nor created motivation to raise application capacity due to lack of specific measures. Therefore, the information technology application activities in teaching is relatively limited, failing to meet the requirements of innovative education and training. From the basis of theoretical and practical research, the article presents the current situation and proposes some measures to manage the application of information technology in teaching at Mien Dong College, Bien Hoa city, in Dong province. Thereby contributing to improving the quality of teaching, meeting the requirements of fundamental and comprehensive reform of education and training in the current period.