Xây dựng tiêu chuẩn cơ sở để kiểm nghiệm dược liệu Tầm bóp (Physalis angulata L.) họ cà (Solanaceae)

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Tác giả: Thiên Hoàng Hồ, Thị Thu Trang Lê, Đức Nhân Nguyễn, Thị Thu Trang Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2023

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Chỉ tiêu chất lượng của Tầm bóp chưa có quy định trong Dược điển Việt Nam gây khó khăn trong công tác kiểm nghiệm. Nghiên cứu này đã đề xuất các chỉ tiêu kiểm nghiệm: mô tả, định tính dược liệu bằng phương pháp hóa học và vi học, thử tinh khiết và xác định chất chiết dựa theo PL12.1 Dược điển Việt Nam V. Kết quả đã mô tả hình thái mẫu cây tươi và dược liệu khô
định tính dược liệu với đặc điểm giải phẫu và bột dược liệu có mảnh biểu bì chứa lỗ khí, lông che chở đa bào, mạch xoắn, mạch vạch, mạch điểm. Trong dịch chiết của Tầm bóp có alkaloid, glycoside tim, flavonoid, tanin, saponin, đường khử, acid hữu cơ và không có courmarin. Đề xuất mức chất lượng cho các chỉ tiêu độ ẩm không quá 8%, vụn nát không quá 4%, tạp chất không quá 0,5%, tro toàn phần không quá 12%, chất chiết được trong dược liệu không ít hơn 12% theo phương pháp chiết lạnh với nước và không ít hơn 8% theo phương pháp chiết lạnh với dung môi ethanol 96%. Kết quả này góp phần tiêu chuẩn hóa nguồn dược liệu Tầm bóp, nhằm sử dụng loài dược liệu này một cách an toàn và hiệu quả.Plants are an important source of medicinal materials. Physalis angulata, family Solanaceae is an edible and medicinal plant in the world and in Vietnam. However, the quality standards of P. angulata have not been specified in the Vietnamese Pharmacopoeia, causing difficulties in testing. This study proposed various test criteria such as description, identification of medicinal herbs by chemical and microscopic methods, purity test and extractives. The results described the morphology of fresh and dried medicinal plants
qualitative medicinal herbs with anatomical characteristics and medicinal powders with fragments of epidermis with stomata, multicellular covering trichomes, helical vessels, scalariform vessels, pitted vessels, etc. In P. angulata extract, there are alkaloids, cardiac glycosides, flavonoids, tannins, saponins, reducing sugars, organic acids and no courmarin. The recommended quality levels for moisture content not more than 8%, crumble not more than 4%, impurities not more than 0.5%, total ash not more than 12%, extractable substances in medicinal herbs not less than 12% by cold extraction with water and not less than 8% by cold extraction with ethanol 96%. This result contributes to the standardization of the medicinal source of Physalis angulata L., in order to use this medicinal species safely and effectively.

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