DÒNG PHỤ SARS-CoV-2 OMICRON BA.5

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Tác giả: Thế Quang Trương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học - Đại học Văn Lang, 2023

Mô tả vật lý: tr.101

Bộ sưu tập: Metadata

ID: 347841

Thêm vào giỏ Liên kết toàn văn

Các biến thể thuộc dòng phụ Omicron BA.5 có 34 đột biến trên protein gai, trong đó có 17 đột biến nằm trong miền liên kết thụ thể (RBD), các đột biến trên RBD tác động làm tăng khả năng liên kết giữa RBD và ACE2, cũng như tạo ra ái lực liên kết cao hơn giữa enzyme chuyển hóa angiotensin 2 (ACE2) và vùng chức năng S1 trên protein gai. Các đột biến H69d, V70d, L452R, F486V trên protein gai của BA.5 cũng làm tăng tốc độ lây lan của virus và tăng khả năng gây bệnh, dẫn đến làm BA.5 dễ lây nhiễm hơn 13 lần so với chủng gốc. Nghiên cứu bước đầu tại Ấn Độ cho thấy, đối với những người đã tiêm chủng đủ ba mũi vaccine COVID-19 có khả năng chống lại BA.5 và giảm khả năng chuyển bệnh nặng. Hiệu quả sao chép của BA.5 kém hơn 10 lần trong mô phổi của người so với chủng gốc, do đó BA.5 gây ra bệnh đường hô hấp ít nghiêm trọng hơn so với chủng gốcThe variants of Omicron sublineage BA.5 has 34 mutations in the spike protein, of which 17 are located in the receptor-binding domain (RBD), the mutations in RBD act to increase the binding ability between RBD and the angiotensin-converting enzyme 2 (ACE2), as well as conferring a higher binding affinity between ACE2 and the S1 functional region in the spike protein. In addition, mutations H69d, V70d, L452R, F486V in the spike protein of BA.5 also increase the speed of virus spread and increase pathogenicity, leading to making BA.5 13 times more infectious than original SARS-CoV-2. Initial research in India shows that people who have received three doses of the COVID-19 vaccine have protection against BA.5 and a reduced likelihood of severe disease transmission. The replication efficiency of BA.5 is 10 times worse in human lung tissue than the parent strain, so BA.5 causes less severe respiratory disease than the original SARS-CoV-2

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