Scientific research is one of the tasks that play a very important role in training creative thinking ability, research capacity and is one of the “important - mandatory - necessary” measures to aim at improving the quality of life. high quality training, better meet the increasingly demanding needs of society. The article introduces the characteristics and compares the advantages and disadvantages of a number of data processing tools in scientific research such as SPSS, STATA, SAS, Eviews,... and big data applications major in scientific research at universities.