Evaluating radionuclides activity in the environment is useful in monitoring human health problems. Radiological aspects of water, soil, and plant in several southern provinces of Vietnam were investigated to present background information about the radiological levels and assess the associated hazards. The research results are intended to contribute to the Vietnamese radioactive background database. Ninetytwo environmental samples (28 water, 36 soil, and 28 plant samples) were collected in the year of 2022 and analyzed for 40K, 232Th, 238U, 226Ra, and 137Cs radionuclides by a High Pure Germanium Detector (HPGe De) low background gamma spectrometer system. The results show that the activity of radioisotopes in soil and plant samples at 06 monitoring points has not fluctuated between points and is equivalent to the values recorded in previous years. Besides, the radioactive isotope 40K in water varies significantly due to salinity intrusion, other isotopes are consistent with the announced activity range (226Ra in water has a lower value than Vietnam standards).