Managing teaching activities of Physics 10 at high schools in Ninh Kieu district, Can Tho city plays a vital role in the early years of implementation of the general education program in 2018. The article presented the current situation of teaching and managing activities of teaching Physics 10 at high schools in Ninh Kieu district, Can Tho city. The results revealed that teaching activities and management of teaching Physics 10 have several strengths, weaknesses and factors affecting the management of teaching Physics 10 at schools in the locality. Based on the findings, the study proposed some measures to manage teaching activities of Physics 10 at high schools in Ninh Kieu district, Can Tho city to meet the requirements of implementing the general education program 2018 in the current period.