Xây dựng công thức và quy trình pha chế theo đơn thuốc bôi da benzyl benzoat 25% dạng gel nhũ tương

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Tác giả: Kim Thuận Nguyễn, Ngọc Như Ý Trịnh, Thị Nhật Duyên Văn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2024

Mô tả vật lý: tr.114

Bộ sưu tập: Metadata

ID: 361542

Thêm vào giỏ Liên kết toàn văn

- Đặt vấn đề: Benzyl benzoat là một trong những thuốc được dùng từ lâu để điều trị bệnh ghẻ với khuyến cáo như là một “can thiệp đầu tay” có hiệu quả và tiết kiệm chi phí điều trị. Mục tiêu của nghiên cứu này nhằm xây dựng một công thức và quy trình pha chế theo đơn thuốc benzyl benzoat 25% bôi da có cấu trúc nhũ tương gel thân nước, để phục vụ cho nhu cầu điều trị của chuyên khoa da liễu.- Đối tượng và phương pháp nghiên cứu: Đối tượng nghiên cứu là thuốc bôi da benzyl benzoat 25% dạng gel nhũ tương. Mô hình thử nghiệm được thiết kế để bào chế được chế phẩm dạng nhũ tương gel thân nước bằng phương pháp “keo ướt”
khảo sát được sự ảnh hưởng của tỷ lệ các chất nhũ hóa, tác nhân tạo gel lên độ bền và thể chất của chế phẩm. Đánh giá sơ bộ chế phẩm qua các chỉ tiêu cơ bản như tính chất cảm quan, pH, mức độ phân bố đồng đều và độ ổn định.- Kết quả: Xác định được một công thức và quy trình bào chế gel nhũ tương benzyl benzoat 25% khá ổn định gồm có: benzyl benzoat (25%), chất diện hoạt không ion hóa (6%), carbopol 940 (0,4%), glycerin (15%), và nước cất (vừa đủ 100%). Chế phẩm thu được có thể chất mềm, mịn, màu trắng đục phù hợp với các tiêu chuẩn chất lượng đề ra.- Kết luận: Đề tài dã xây dựng được công thức và quy trình pha chế theo đơn gel nhũ tương benzyl benzoat 25% và phù hợp với các chỉ tiêu chất lượng của mục tiêu nghiên cứu. Abstract - Background: Benzyl benzoate is one of the older preparations used to treat scabies with recommendations as an effective “first - line treatment” and saving treatment costs. The gold of this research is building a formula and compounding process for 25% benzyl benzoate medication under hydrophilic emulgel structure, supplying a rare preparation for currently demand of therapy in dermatology.- Materials and methods: The materials is benzyl benzoat 25% emulgel for topical delivery. The experimental models was designed to prepare an hydrophilic emulgel by “wet gum” method
examine the influence ofthe ratio of emulsifiers, gelling agents on the stability and physical properties of thepreparation
the preliminary evaluation of emulgel via the main criteria such as: appearance, pH, homogeneity of distribution and stability.- Results: The experimental results has determined the optimal formulation and compounding process for benzyl benzoate 25% emulgel including: benzyl benzoate (25%), non - ionic surfactant (6%), carbopol 940 (0,4%), glycerin (15%) and distilled water (q.s.100%). The finished product is soft, smooth, with milky white opaque color and comfort to quality standards of the objectives.- Conclusion: The project has developed the formula and the compounding process of benzyl benzoate 25% emulgel and comfort to some basic quality standards objective. DOI: 10.59715/pntjmp.2.4.10

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