Đánh giá các dấu ấn chuyển hóa liên quan đến mật độ xương ở phụ nữ bị loãng xương sau mãn kinh

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Tác giả: Phạm Thục Lan Hồ, Như Huỳnh, Duy Linh Mai, Thanh Sơn Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2024

Mô tả vật lý: tr.176

Bộ sưu tập: Metadata

ID: 361679

Thêm vào giỏ Liên kết toàn văn

- Đặt vấn đề: Loãng xương với hệ quả gãy xương là một bệnh chuyển hóa xương phổ biến. Các dấu ấn sinh học về mật độ xương (MĐX) rất hữu ích cho việc phòng ngừa và chẩn đoán sớm loãng xương và gãy xương.- Mục tiêu: Nghiên cứu này nhằm xác định các dấu ấn sinh học chuyển hóa của MĐX.- Đối tượng: 100 phụ nữ sau 50 tuổi, trong đó 50 người bị loãng xương và 50 người không mắc bệnh.- Phương pháp: Thiết kế bệnh chứng (Case-control study). Xác định các metabolites có liên quan đến bệnh với phương pháp định danh không mục tiêu bằng hệ thống LC-MS/MS. Chẩn đoán loãng xương dựa vào đo mật độ xương tại 2 vị trí cổ xương đùi (FNBMD) và cột sống lưng (LSBMD), bằng kỹ thuật DXA với máy Hologic Horizone.- Kết quả: Từ 166 chất chuyển hóa được định danh trong nghiên cứu, chúng tôi ghi nhận được 12 chất có sự khác biệt có ý nghĩa thống kê (p <
0,0001) giữa nhóm loãng xương và nhóm không loãng xương. Trong đó có 2 chất liên quan đến MĐX thấp (LSBMD) gồm L-Carnitine và Glycerophosphocholine và 1 chất giúp tăng MĐX (FNBMD), mối liên quan vẫn duy trì có ý nghĩa thống kê sau khi điều chỉnh cho các yếu tố độ tuổi, BMI, hoạt động thể chất.- Kết luận: Bước đầu nghiên cứu xác định được một số chỉ dấu chuyển hoá của MĐX, tiềm năng hỗ trợ cho các chỉ số lâm sàng hiện tại giúp phát hiện sớm và phòng ngừa loãng xương. Abstract - Background: Osteoporosis is a prevalent metabolic bone disorder, often resulting in osteoporotic fractures. Biomarkers for assessing bone mineral density (BMD) play a vital role in the prevention and early detection of osteoporosis.- Objectives: This study aims to elucidate the metabolites associated with BMD.- Subjectives: 100 women aged 50 and above were recruited, evenly split into 50 with osteoporosis and 50 without. - Methods: Employing a case-control approach, we conducted non-targeted metabolite identification utilizing the LC-MS/MS system. Osteoporosis diagnosis relied on the measurement of bone density at two locations femoral neck (FNBMD) and lumbar spine (LSBMD), assessed through DXA utilizing the Hologic Horizon machine. - Results: Among the 166 identified metabolites in our study, we observed statistically significant differences (p <
0.0001) between the osteoporosis and non-osteoporotic groups for 12 specific substances. Of these, two metabolites, L-carnitine and Glycerophosphocholine, exhibited association with low LSBMD, while one metabolite was linked to increase FNBMD. Theseassociations retained statistical significance even after adjusting for factors such as age, BMI, and physical activity.- Conclusion: Our findings suggest that metabolomics profiling holds promise for identifying novel BMD biomarkers, potentially advancing the early diagnosis and prevention of osteoporosis, supplementing the current clinical indices. DOI: 10.59715/pntjmp.2.4.18

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