KHẢO SÁT HOẠT TÍNH CHỐNG OXI HOÁ VÀ CHỐNG LOÃNG XƯƠNG CỦA CÁC HỢP CHẤT PHÂN LẬP TỪ HOA CÚC HOA VÀNG

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Tác giả: Thi Thu Trang Bui, The Hoai Le, Thi Huong Nguyen

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học & Công nghệ - Trường Đại học Công nghiệp Hà Nội, 2023

Mô tả vật lý: tr.116

Bộ sưu tập: Metadata

ID: 365207

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In this research, five compounds were isolated from Chrysanthemum indicum L flowers and determined their structures to be Syringin (1), Dihydrosyringin (2), Benzyl-O-β-D-glucopyranoside (3), -Phenylethoxy-O--D-glucopyranoside (4), and (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside (5) by analysis 1D - NMR spectra and compared to literatures. These compounds were investigated antioxidative and anti-osteoporosis activities. Among them, compound 5 showed the best antioxidant activity at a concentration of 10µM with the value of peroxyl radical scavenging to be 11.39 ± 0.11 times higher than the protection provided by 1.0 μM Trolox and compound 2 exhibited meaningful reducing capacity, with CUPRAC values of 11.24 ± 0.01 at 10µM. Compound 5 also exhibited the best anti-osteoporosis effect at a concentration of 10.0µM with percent of inhibition on RANKL-induced osteoclast differentiation of 151.16 ± 13.13%.Trong nghiên cứu này, 5 hợp chất gồm Syringin (1), Dihydrosyringin (2), Benzyl-O-β-D-glucopyranoside (3), -Phenylethoxy-O--D-glucopyranoside (4) và (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside (5) đã được phân lập từ hoa cúc hoa vàng (Chrysanthemum indicumL). Các hợp chất phân lập được được xác định cấu trúc qua các phân tích phổ cộng hưởng từ 1H và 13C, kết hợp so sánh với tài liệu tham khảo. Các thử nghiệm về hoạt tính chống oxi hoá và chống loãng xương của các hợp chất này đã được thực hiện. Kết quả cho thấy, hợp chất 5 thể hiện hoạt tính bắt giữ gốc tự do peroxyl tốt nhất ở nồng độ 10μM với giá trị hoạt tính cao gấp 11,39 ± 0,11 lần với khả năng chống oxi hóa của Trolox 1,0μM, hợp chất 2 thể hiện khả năng khử ion đồng (I) tốt nhất ở 10 μM với giá trị hoạt tính là 11,24 ± 0,01 tại 10μM. Hợp chất 5 cũng thể hiện hoạt tính chống loãng xương tốt nhất ở nồng độ 10,0μM với giá trị phần trăm ức chế sựgiảm tế bào hủy xương do RANKL gây ra ở cùng nồng độ là 151,16 ± 13,13%.

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