This is a reprint of the Special Issue "Urban-Rural-Partnerships: Sustainable and Resilient" in Land, which, based on the URP2020 objectives, invited original contributions dealing with interactions in regional systems, particularly between urban and rural actors, institutions and projects to tackle great societal challenges. The 16 contributions published included conceptual and methodological papers, as well as case studies dedicated to striking examples and providing transferable knowledge and solutions. The guest editors hope that the contributions will stimulate learning processes on various levels, i.e. cross- and transdisciplinary as well as from the local level to entire regions to the broader European and international levels, in order to foster an understanding of integrated regional and urban-rural development.