Objective: In this study, we aim to investigate the serum glucose level in children with epilepsy. Method: A cross-sectional study was conducted at the Pediatric Center of Hue Central Hospital between June 2017 and June 2019. A serum glucose level test was performed after the seizure. Results: A total of 144 patients were included in the study. Among these, the predominant age group was 0 - <
5 years (accounted for 59.7%), followed by group 5 - 10 years (24.3%) and 11 - 15 years (16%). Female was more likely than male (52.8% vs 47.2%). The most common type was generalized epilepsy (accounted for 72.2%), and the least was un-classified epilepsy (6.3%). The blood test results revealed 19 (13.2%) of patients with hyperglycemia and 1 (1.4%) with hypoglycemia. Conclusion: The present study highlighted that seizure can cause glycemic disorder in children with epilepsy.