Introduction: High-risk neuroblastoma is a childhood malignancy with a poor prognosis. Gradual improvements in survival have correlated with therapeutic intensity, and the ability to harvest, process and store autologous hematopoietic stem cells has allowed for dose intensification beyond marrow tolerance. Case: We report two cases which were diagnosed high risk neuroblastoma. The first case had big heterogeneous at his left adrenal gland with metastasis in bone marrow and his brain. The second case with localised tumor at her right kidney and NMYC positive. Both cases were treated with SIOPEN protocol, starting with 8 course RAPID COJECT. Patients had partial response and were collected stem cells. Then they were primary tumor resection
receiving high dose chemotherapy with autologous- stem cell rescue, radiation and retino acid treatment, respectively. Conclusion: This is initially report of autologous stem cell transpant for high risk neuroblastoma. Even only two patients, the results showed that stem cell transplant was safe and effective. We are continuing to implement for more case with high risk neuroblastoma and will have better report with a bigger number.