The article collection of this Special Issue reprint covers a wide range of neurorehabilitation modalities, although they only represent a small proportion of the whole scene. We trust that they will assist clinicians in performing evidence-based interventions and illuminate the necessity of multidisciplinary collaboration. Furthermore, they share an important motivational drive, that is, the inspiration to move forward to a new era where medical, basic research, engineering, and high-tech advances can develop more efficacious approaches, combining neuromodulation techniques under sophisticated neuroimaging guidance. These can be widely and remotely applied to all people that need them, organized under a fresh "patient-centric" approach, with home-based and tele-rehabilitation protocols replacing long stays in medical centers.