This volume is a reprint of the Honorary Special Issue dedicated to the 60th birthday of Professor Dr. Kalyanmoy Deb, published in the journal Mathematical and Computational Applications (MCA). Kalyanmoy Deb has been a pioneer and highly impactful and influential proponent of Evolutionary Multi-objective Optimization (EMO) since 1994. He is currently a Koenig Endowed Chair Professor and University Distinguished Professor in the Department of Electrical and Computer Engineering at Michigan State University, USA, and holds additional appointments in Mechanical Engineering and in Computer Science and Engineering. Professor Deb's research interests are in evolutionary optimization and its application in multi-objective optimization, modeling, machine learning, and in multi-objective decision making. He has been a visiting professor at various universities across the world, including IITs in India, Aalto University in Finland, the University of Skovde in Sweden, and Nanyang Technological University in Singapore. He was awarded the IEEE Evolutionary Computation Pioneer Award, the Infosys Prize, the TWAS Prize in Engineering Sciences, the CajAstur Mamdani Prize, the Distinguished Alumni Award from IIT Kharagpur, the Edgeworth Pareto Award, the Bhatnagar Prize in Engineering Sciences, and the Bessel Research Award from Germany. He is a fellow of IEEE, ASME, and three Indian science and engineering academies.