Objective: Determine the value of propofol target in the brain based on the electroencephalography (EEG) of entropy in anesthesia in cardiac surgery. Investigations of hemodynamics, respiratory changes and endotracheal extubation in these patients. Subjects and methods: A study of 50 patients with heart valve surgery was planned to target intra venous anesthesia with propofol in combination with entropy digitizing electroencephalography (RE, SE), aged 16-60, ASA II, III, EF >
40%. Record the value of Ce during the maintenance period to achieve RE, SE in the range 40-60. Results: Ce-propofol values during intubation ranged from 2.93 ± 0.70 to 3.14 ± 0.79 mcg/ml, the aver age loss of consciousness and the onset of anesthesia were 46.78 ± 11.58 seconds and 12.8 ± 2.9 minutes, the concentration for pre-circulatory surgical procedures ranged from 3.28 ± 0.85 to 3.72 ± 0.94 mcg/ml, at the time when the extracellular circulation began to take on a total of 3.55 ± 0.96 mcg/ml and the period after the extracorporeal period ranged from 2.79 ± 0.62 to 2.84 ± 0.62 mcg/ml, the average anesthetic time is 263.3 ± 44.4 minutes. Heart rate, blood pressure, and respiration were maintained stably, average intu bation time was 4.20 ± 0.96 hours. Conclusion: Propofol’s target concentration in the brain based on entropy digitized electroencephalog raphy during the onset of anesthesia and maintenance for cardiac surgery is Ce 2.93 ± 0.70 to 3.14 ± 0.79 mcg/ml and 2.79 ± 0.62 to 3.72 ± 0.94 mcg/ml, 100% early extubation.