Background: Osteochondritis and periostitis often occur in children with symptomatic congenital syphilis, manifest by decreased limb movement due to secondary ostealgia mimicking paralysis in some neurological disorders. Clinicians may not recognize this sign and confuse it with other neuropathy, leading to a delay in diagnosis and treatment or excessive investigations. Objectives: Describe the sign of pseudoparalysis of Parrot in congenital syphilis. Design: A descriptive case report at the Infectious Disease Department of Children’s Hospital No.2 , Ho Chi Minh City, Vietnam. Case Study: a 35-day-old girl, presented with progressive reduction of upper limbs movement within 5 days, no other abnormalities except reduction of hands movement and crying loudly when trying to passively move limbs, Positive for VDRL and RPR tests. Her mother got syphilis on a prenatal screening test. She was treated with penicillin G and fully recovered. Conclusion: pseudoparalysis of Parrot is easily confused with other neuropathy, fully recovered after treatment with penicillin.