The formation of salivary gland stone, also known as Sialolithiasis, is the most common disorder of the salivary glands. Sialolithiasis usually occurs in middle age and are most common within the body of sub mandibular gland or Wharton’s duct (80-85%), followed by the parotid gland (5 - 10%) sublingual glands and minor salivary glands (5%). Nowadays, it is not difficult to diagnose of sialolithiasis immediately due to the support of several non-invasive diagnostic methods (Ultrasound, CT-Scanner and CT-Conebeam…). However, the management of parotid sialolithiasis is still limited. There is lack of dosmetical and inter national studies talking about the treatment for this disorder. Obviously, this is a huge challenge for oral maxillo - facial (OMF) surgeons in terms of big-sized radiolucent stones, especially when they are located in hard - approaching positions of ducts. In recent decades, the application of Medical Laser in lithotripsy is a groundbreaking management in urological surgery and other departments, such as dermatology, plastic surgery, ENT, dentistry, OMF surgery… Odonto - Stomatology Center is stayed in Hue Central Hospital, which was awarded the Special Class, was updated Laser techniques and was able to cooperate with many departments. This is the reason why our team decided to perform an all-new technique: Yag - Holmium laser sialendoscopy treatment of parotid sialolithiasis with ultrasound-assisted in Odonto - Stomatology Center. This research contributes to propose and complete the protocol for this all-new technique, in order to improve the management of parotid salivary stones. Initial reviews show that sialendoscopy with holmium: YAG laser lithotripsy can overcome the limita tions of open- surgery (prostate, facial paralysis, and vascular lesions). In this preliminary study, our team reports ours experience in sialendoscopy with holmium: YAG laser lithotripsy with ultrasound guidance. Patients were followed up and re-examined for clinical symptoms and glandular ultrasound at 3 months and 6 months postoperatively. Re-examination results showed no complications and recurrence of stones, normal parotid gland function and no narrowing of the gland duct.