Study on clinical and subclinical features of Henoch-schönlein purpura in children

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Tác giả: Dang Thi Nguyen, Hung Viet Phan, Kiem Hao Tran

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Clinical Medicine – Hue Central Hospital, 2020

Mô tả vật lý: tr.31-39

Bộ sưu tập: Metadata

ID: 377201

 Objective: Describe clinical and subclinical characteristics of Henoch-Schönlein purpura in children. Find the relationship between kidney lesion and clinical and subclinical manifestations. Subjects and Methods: Cross-sectional descriptive study, including 51 children <
 15 years of age diagnosed with Schonlein-Henoch purpura being treated at Hue Central Hospital and Hue University Hospital from April 2016 - May 2018. Results: 51 children entered the study: Male:Female =1.3:1
  mean age 7.5 ± 3.4 years. At onset, purpura was present in all cases, gastrointestinal manifestations in 66.7%, arthritis/arthralgias in 54.9%, renal lesion in 19.6%. The most frequent laboratory abnormalities were Leukocytosis (WBC >
 10 x 109 /L) in 60.8%, high-erythrocyte sedimentation rate (ESR) in 80.4%, microscopic hematuria in 15.7%, proteinuria in 13.7%. Renal lesion were correlated with age of onset. The age group>
  10 years old has 6.1 times more kidney lesion than the group ≤ 10 years (OR: 6.1
  95% CI (1.5-26). Conclusion: Clinical and subclinical findings of Schonlein-Henoch purpura in our study are similar to those in the literature. There is an relationship between the age of onset with kidney lesion.
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