Objective: Evaluation of hematology indicator for plateletapheresis donors and the quality of platelets units separated from Amicore machine . Subject of research: Platelet donors at Hue Blood Transfusion Center. Material and methods: Cross-sectional description study. Results: We investigating 30 donors: Red blood cells, hemoglobin, hematocrit, leucocyte and platelet decreased related to the previous collection (p<
0.001). All donors were safe, adversed reactions mainly occur in mild citrate poisoning, feeling of numbness lips was 13.33%. The average volume of platelets was 271.50 ± 25.41 ml. The average platelet count was 310.30 ± 21.57 x 109 /a unit. 100% of platelet units achieve quality standards according to AABB standards, quality according to 26 Circular Ministry of Health in 2013. Conclusion: All donors were safe and 100% of platelet units passed AABB quality standards and Ministry of Health quality