Background: Kidney transplantation in chronic renal failure patients with high anti-HLA antibodies is very difficult, very likely to occur acute rejection, Thus, it requires to have strong immunosuppressive regimens for pre-transplantation and post-transplantation. Objectives: 1. Evaluate the results of kidney transplant in patients with high level of anti HLA antibodies. Evaluate the effectiveness of the introduction therapy. Patients and methods: There were 3 patients with high anti-HLA antibodies: 62%, 89% and 97%, HLA matching 2/6, 3/6 and 3/6, respectively, in the same blood group. A patient had a first kidney transplant (chronic rejection), 2 patients had a history of transfusion. All of them have had kidney transplantation at Hue Central Hospital from 2015 to 2017. Results: All three patients received a successful kidney transplantation. There was one post-transplant acute rejection patient must be treated by acute rejection therapy and dialysis in 12 times
an anemic patient must be treated by EPO. All three patients discharge from hospital with normal renal function, clinical stability. Conclusion: With high positive Anti HLA antibodies, kidney transplantation with can by tanssplanted with certain success rate. However, it is necessary to have strong immunosuppressive regimens, especially using induction therapy of ATG