Local inflammation associated with the peripheral intravenous cannula insertion is an important issue in nursing care which can lead to sepsis.Objective: (1) Determination local inflammation rate associated with the use of peripheral intravenous catheter (2) the risk factors of local inflammation caused by peripheral intravenous catheter insertion.Methods: A cross sectional study of 510 patients using peripheral intravenous catheter (PIC) in Hue Central Hospital. Inflammation level was assessed on the VIP scale.Results: The incidence of local inflammation was (28,0%) while using PIC, with local inflammation Grade I was the highest proportion (45.5 %), Grade II was (35.0%), Grade III was (11.9%) and Grade IV was (7.6%). There is no Grade V. The risk factors of local inflammation after using PIC including: age (≥ 60), length of admission (>
5 days), the number of catheter placement (≥ 4), time catheter remained in place (≥ 3) days, group drug was protein - polymer. Recommendations: Observe to detect local inflammation soon after using PIC to improve the qualityof patient care.