Background: Extranodal NK/T-cell lymphoma, nasal type, is a rare subtype of non-Hodgkin lymphoma,origin from natural killer (NK) cells and T cells. This is a rare, fast-growing and poor prognosis disease.Currently there have been not many studies in Vietnam on this issue. We conduct this research with twoobjects: to describe characteristics of patients and evaluate premininary results of treatment extranodalNK/T cell lymphoma, nasal type, stage I to II at K hospital.Methods: Retrospective study. From January 2017 to June 2020, we enrolled 26 patients with extranodalNK/T cell lymphoma, nasal type, stage I to II. Patients were treated concurrent chemoradiotherapy withcisplatin, followed by 3 cycles of VIPD adjuvant regimen.Results: Patient characteristics: The average age was 43.2. Male/female ratio was 1.36. The mostcommon symptoms were stuffy of nose 84.6%
runny nose 65.4%. Peripheral lymph nodes observed in19.2%
50% with B symptom. Staged I was dominated with 73.1%.Treatment results: Concurrent chemoradiotherapy phase: completed response was 26.9%, partialresponse 53.8% and progression disease 19.2%. At the end of treatment course, the overall response ratewas 73% (including 61.5% completed response and 11.5% partial response), 26.9% cases with diseaseprogression.Toxicity: Leukopenia was the most common toxicity (61.1%). Grade III and IV leukopenia were observedin 18.4%.Conclusions: Concurrent chemoradiotherapy followed by adjuvant VIPD regimen with stage I, II iseffective regimen and acceptable toxicity