Background: Covid-19 patients need a combination of treatment methods, including respiratory rehabilitation. This study aims to evaluate the effectiveness of the Respiratory Rehabilitation Program in Covid-19 patients. Methods: A cross - sectional descriptivestudy was carried out in 65 patients with severe and critical Covid-19 pneumonia who were receiving improved treatments at the Intensive Care Center of Hue Central Hospital in Ho Chi Minh City. The patient’s ability to recover after one week was re - evaluated based on SpO2 index, Borg dyspnea scale and Barthel’s independent life scale. The effectiveness of respiratory rehabilitation was compared using the Wilcoxon sum test. Results: The age ranged from 19 to 93 years. The age group from 50 to 59 years old was made up the largest proportion, accounting for 29.2%. The prevalence was higher in women than men (56.9% vs. 43.1%, respectively). The shortest hospital stay was six days, and the longest was 47 days. The patients experienced respiratory rehabilitation exercises from the beginning when they were admitted to the hospital and throughout their stay. Hypertension was the most common underlying disease factor, accounting for 61.8%. Ventilation support measured or oxygen therapy using mask cannula is the main factor accounting for 96.5%. SpO2 statistically increased from 98% (95.5 - 99%) to 99% (97 - 100%) (p <
0.05). The Borg dyspnea scale statistically decreased from 2 (1 - 4) to 1 (0.5 - 2) (p <
0.05). Barthel’s independent functional - life scale statistically increased from 80 (67,5 - 100) to 100 (80 - 100) (p <
0.05). Conclusion: Respiratory rehabilitation program contributes to the recovery of Covid-19 patients