Áp dụng hóa bảng phân loại của st gallen 2013 trong phân nhóm phân tử ung thư vú biểu mô tuyến vú

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Tác giả: Van Chu Nguyen

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Clinical Medicine – Hue Central Hospital, 2020

Mô tả vật lý: tr.110-116

Bộ sưu tập: Metadata

ID: 379311

Thêm vào giỏ Liên kết toàn văn

Molecular classification of breast cancer is target to category patient groups who need to treat by theappropriate adjuvant therapy and provide more exact prognostic information.Purpose: Determining the proportion of molecular types and commenting on some association withclinicpathological characteristics of breast cancer.Methods: 521 operated breast cancer patients were stained by immunohistochemistry with markessuch as: ER, PR, HER2, and Ki67 for classifying into 5 molecular categories and follow up assessment.Results: Type LUMBH- accounted for the highest proportion of 26.5%, followed by luminal A (22.5%).Typically, LUMA was the highest rate in good NPI (35.0%), whereas in poor NPI group, HER2 type was thehighest rate (36.4%) (p<
0.001). The LUMBH - group has the OS rate during the 5-year follow-up of 94.6% and LUMA is 93.5%
In contrast, the HER2 group showed the lowest OS ratio (72.6%) (p<
0.05Conclusion: Molecular classification of breast cancer according to St Gallen 2013 classification canprovide the important information for treatment and prognosis.Phân typ phân tử ung thư vú nhằm xác định chính xác các nhóm bệnh nhân cần được điều trị bổ trợ và cung cấp các thông tin dự báo tiên lượng bệnh chính xác. Mục tiêu: Xác định tỷ lệ các typ phân tử và nhận xét một số mối liên quan với đặc điểm GPB-LS ung thư biểu mô tuyến vú. Đối tượng và phương pháp nghiên cứu: 521 bệnh nhân ung thư vú sau phẫu thuật cắt tuyến vú được nhuộm hóa mô miễn dịch với ER, PR, HER2, Ki67 để phân typ phân tử ung thư vú và theo dõi sau điều trị. Kết quả nghiên cứu: Typ LUMBH- chiếm tỷ lệ cao nhất 26,5%, tiếp đến lòng ống A (22,5%). Typ LUMA chiếm tỷ lệ cao nhất ở NPI tốt là 35,0%, trái lại ở NPI xấu, typ HER2 chiếm tỷ lệ cao nhất là 36,4% (p<
0,001). Nhóm LUMBH- có tỷ lệ OS trong thời gian theo dõi 5 năm là 94,6% và LUMA là 93,5%
ngược lại, nhóm HER2 thể hiện ở tỷ lệ OS thấp nhất (72,6%) (p<
0,05). Kết luận: Phân typ phân tử ung thư vú theo bảng phân loại của St Gallen 2013 có thể cung cấp các thông tin quan trọng cho điều trị và tiên lượng bệnh.

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