Nghiên cứu đặc điểm mô bệnh học và hóa mô miễn dịch của ung thư phổi tại khoa giải phẫu bệnh

Nghiên cứu đặc điểm mô bệnh học và hóa mô miễn dịch của ung thư phổi tại khoa giải phẫu bệnh - bệnh viện trung ương Huế

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Tác giả: Phuoc Thi Doan, Van Tuan Nguyen, Nguyen Cuong Pham, Dinh Hung Tran, Thi Phuong Hoa Vo

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Clinical Medicine – Hue Central Hospital, 2020

Mô tả vật lý: tr.23-28

Bộ sưu tập: Metadata

ID: 379317

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Chẩn đoán và phân loại mô học ung thư phổi (UTP) trên thực tế gặp rất nhiều khó khăn, đặc biệt là những mẫu sinh thiết nhỏ. Do đó, việc sử dụng các dấu ấn hóa mô miễn dịch đặc hiệu để xác định chính xác các typ mô bệnh học, phản ánh được tiên lượng và chỉ định điều trị ung thư phổi là điều hết sức cần thiết. Mục tiêu: Đánh giá đặc điểm mô bệnh học ung thư phổi. Áp dụng sự bộc lộ các dấu ấn miễn dịch để phân loại ung thư phổi. Sự bộc lộ các dấu ấn miễn dịch như CK7, TTF1, CK5/6, P63 đế phân biệt tế bào u biệt hóa theo hướng tuyến hay gai và các dấu ấn TTF1, NSE, Synaptophysin, Chromogranin để xác định UTBM tế bào nhỏ của phổi là rất hữu ích trong chẩn đoán, phân loại và điều trị ung thư phổiThe diagnosis and classification of lung cancer histology often face to many difficulties in pathologicalpractice, especially on small core biopsies. Therefore, there is a need the immunohistochemistry for determiningthe exact types of histopathology, reflecting prognosis and indications for treatment of lung cancer. Objective: Evaluation characteristics histological of lung cancer. Applying the revealing ofimmunohistochemistry to classify the lung cancer.Matherial and Method: Through a study on 124 patients were diagnosed as lung cancer at Hue CentralHospital from June, 2016 to June, 2019. Prospective, descriptive, cross- sectional study.Results: - Ratio Male: Female: 2,45 / 1. The average age is disease 54,16 ± 12, the lowest age: 17,maximum: 77. The highest group is 50-69 years old (58,07%). The two most common types of histologyare adenocarcinoma (46.77%), squamous cell carcinoma (30.65%), Small cell mesothelioma accounts fora very low rate (5.65%).- On the expression of immunohistochemistrical markers in adenocarcinoma: CK7 (+): 98.28%
TTF1(+): 96.55%
CK5 / 6 (-): 100%, in squamous cell carcinoma: CK5 / 6 (+): 92.11%. P63 (+): 52.63%, TTF1(-): 100%.Conclusion: The expression of immunohistochemistrical markers such as CK7, TTF1, CK 5/6, P63distinguishes between the gland cells and squamous cell, while immunohistochemistrical markers suchas TTF1, NSE, Synaptophysin, Chromogranin to identify small cell carcinoma of the lung are very useful indiagnosing, classifying and treating the lung cancer.

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