Objective: This study aims to explore the characteristics of periampullary cancer and laparoscopic pancreaticoduodenectomy procedure. Methods: We prospectively examined data of 11 patients who underwent laparoscopic pancreaticoduodenectomy at Hue Central Hospital from november, 2018 to november, 2021.Results: The mean age was 53.7 ± 9.5 years (30 - 78) and the male/Female ratio was 8:3. The Body mass index of patients was 54.5% and normal level was 45.5%.patients with ampulla of Vater cancers accounted for 81.8% and duodenal tumor accounted for 9.1% and distal common bile duct tumor accounted for 9.1%. Dilatation of the common bile duct was 90.9% and the pancreatic duct was 72.7%. There were 36,4% the tumor size less than 2 cm and from 2 - 3 cm was 54.5% and less than 4 cm was 9.1%. We was always used in 5 trocars and the dissection lymphadenectomy ratio from 7 - 14 lymph nodes accounted for 81.8%. Bleeding complications during surgery was 27.3% and death was 18.2% patients. Conclusion: The ampulla of Vater and tumor size less than 3 cm was often selected for laparoscopic pancreaticoduodenectomy. Dissection lymphadenectomy also performed well. Less pain after pancreaticoduodenectomy surgery and short hospital stay times.