Background: Ear infections are usually caused by viral, bacterial or fungal pathogens. Some species of bacteria are highly resistant to antibiotics such as Streptococcus pneumoniae, Pseudomonas aeruginosa, methicillin-resistant Staphylococci… The misuse of antibiotics has led to the development of antibiotic- resistant bacteria and antibiotics have become less effective. Our study aimed to detect common bacteria causing ear infections in pediatric patients and drug resistance of these bacteria at Da Nang Hospital for Women and Chidren. Methods: A descriptive cross-sectional study was conducted on 93 purulent fluid samples from pediatric patients at Da Nang Hospital for Women and Children from October 2019 to April 2020. Bacteria strains causing ear infections were identified and detected antibiotic resistance by Vitek 2 compact and Kirby - Bauer method. Results: Among the 93 samples, 11 bacteria species causing ear infections were found, with the 4 most common types being: Staphylococcus aureus (37.6%), Pseudomonas aeruginosa (18.2%), Haemophilus influenzae (17.2%) and Streptococcus pneumoniae (13.9%). S. aureus showed resistance to methicillin with the rate of 88.6%, 100% resistance to penicillin, high resistance to azithromycin, clindamycin, erythromycin and oxacillin (80.0 - 91.4%). P. aeruginosa was completely sensitive to gentamycin, tobramycin, ciprofloxacin, colistin
relatively resistant to cefepime with the rate of 11.8%. H. influenzae resisted most antibiotics (>
50%) in the group B, C and O, was completely sensitive to levofloxacin. Streptococcus pneumoniae was completely resistant to erythromycin, highly resistant to trimethoprim/ sulfamethoxazole in antibiotic group A with the rate of 84.6%, completely resistant to clindamycin, completely sensitive to antibiotics in group B, C and O. Conclusions: Bacteria that cause ear infections were mainly Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenza and Streptococcus pneumoniae. Ear infectious bacteria often resisted most common antibiotics.