Introduction: Evaluating the feasibility and safety of the technique and the results totally laparoscopic total gastrectomy (TLTG) with D2 lymph node dissection and functional end - to - end esophagojejunostomy by linear stapler without previous resection of esophagus and jejunum in the treatment of gastric adenocarcinomar. Materials and Methods: A prospective descriptive study, 70 patients with gastric adenocarcinoma between July 2017 and November 2020 at the Nghean Friendship General Hospital. Results: The average age of 62.47 ± 11.6 years. The male/female ratio was 2.5/1. The percent of patients with tumors at stages I, II, III were 21,4%, 45,7%, 32,8%. 80.0% of patients had papillary adenocarcinoma and tubular adenocarcinoma, 15.7% of patients had ring cell carcinoma. The average number of harvested lymph nodes was 23,2 ± 6,7. The average number of metastatic lymph nodes was 2.77 ± 3.8. The average blood loss was 32.29 ± 10.09 ml. The average operation time 202,2 ± 28,9 minutes. The total percent of incidents during the surgery was 4.2% and the total percent of postoperative complications was 4.2%. The success rate of the technique of TLTG with D2 lymph node dissection and functional end-to-end esophagojejunostomy by linear stapler without previous resection of esophagus and jejunum was 100%. The hospital stays was 7.3 ± 1.9 days and the survival time after surgery was 40,14 ± 1,73 months. The survival rates of one year, two years, three years were 98.6%, 92.1%, 75.9%. Conclusions: TLTG with D2 lymphanectomy and functional end - to - end esophagojejunostomy without previous resection of esophagus and jejunum was feasibility, safety and effective in the treatment of gastric adenocarcinoma.