Đánh giá ảnh hưởng của hốc khí và trường chiếu nhỏ tới phân bố liều của kế hoạch jo - imrt trên bệnh nhân ung thư đầu cổ bằng phương pháp monte carlo

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Tác giả: Thanh Tai Duong, Thi Oanh Luong, Thi Hong Loan Truong

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Clinical Medicine – Hue Central Hospital, 2020

Mô tả vật lý: tr.50-55

Bộ sưu tập: Metadata

ID: 379362

Thêm vào giỏ Liên kết toàn văn

Mục đích của nghiên cứu này là sử dụng phương pháp mô phỏng Monte Carlo (MC) để đánh giá ảnh hưởng các hốc khí trong phantom và bệnh nhân ung thư đầu cổ điều trị bằng kỹ thuật JO - IMRT. PDF với các kích thước trường 1×1, 2×2, 3×3, 4×4 và 5×5 cm2 tương ứng là 62,04%
52,34%
40,71%
26,72% và 19,85%. Kết quả cũng cho thấy liều hấp thụ trung bình trong PTV của bệnh nhân tính bằng MC (65,58 Gy) thấp hơn liều tính toán từ TPS (71,41 Gy). Từ nghiên cứu này, chúng tôi kết luận rằng việc giảm liều ở vùng tiếp giáp mô/không khí tác động đáng kể đến độ chính xác của phép tính liều JO-IMRT ở bệnh nhân ung thư đầu cổ (H & N).Purposes: The goal of this study was to use Monte Carlo (MC) simulation to examine the dosimetriceffects of the air cavity on JO-IMRT dose distribution at air-tissues interfaces in head-and-neck (H&N) patients. Methods: The EGSnrc - MC code system was used to calculate the dose reductions in air-tissue interfaceregion for single field irradiations with 1×1, 2×2, 3×3, 4×4, and 5×5 cm2 in solid acrylic phantoms (30×30×20cm3) and seven fields in a JO-IMRT plan. With phantom, the PDD values in both with and without an aircavity (15×4×4 cm3) which is 2.5 cm away from the anterior surface of phantom were used to evaluate. Withthe JO-IMRT plan, the dose-volume histograms (DVH), slice by slice isodose, and the gamma index usingglobal methods implemented in PTW-VeriSoft with 3%/3 mm criteria were used to evaluate.Results: The study results indicate that the dose reductions in the air-tissue interface region of thephantom are strongly dependent on field size. The average percentage dose reductions at 1 mm from theair-water interface for the field size 1×1, 2×2, 3×3, 4×4, and 5×5 cm2 are 62.04%, 52.34%, 40.71%, 26.72%,and 19.85%, respectively. Additionally, the mean MC dose in the PTV (65.58 Gy) of patients were lowerthan the TPS predicted dose (71.41 Gy).Conclusions: From this study, we conclude that the dose reduction in near air-tissue interfaces is asignificant effect on JO-IMRT dose distribution in head-and-neck (H&N) patients.

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