Bất thường nhiễm sắc thể và liên quan tới kết quả điều trị sớm lơ xê mi cấp dòng lympho trẻ em tại viện huyết học - truyền máu trung ương giai đoạn 2016

Bất thường nhiễm sắc thể và liên quan tới kết quả điều trị sớm lơ xê mi cấp dòng lympho trẻ em tại viện huyết học - truyền máu trung ương giai đoạn 2016 - 2019

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Quoc Khanh Bach, Thi Hong Hoang, Lan Mai, Quang Tung Nguyen, Trieu Van Nguyen

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Journal of Clinical Medicine – Hue Central Hospital, 2020

Mô tả vật lý: tr.81-87

Bộ sưu tập: Metadata

ID: 379366

Thêm vào giỏ Liên kết toàn văn

Biến đổi di truyền tế bào trong lơ xê mi cấp dòng lympho trẻ em có vai trò quan trọng trong tiên lượng và chia nhóm nguy cơ. Đánh giá kết quả điều trị sớm theo đặc điểm di truyền tế bào cung cấp thêm các dữ liệu cho các bác sỹ trong lựa chọn phương pháp điều trị cho bệnh nhi. : Nghiên cứu đặc điểm bất thường nhiễm sắc thể (NST) và đánh giá mối liên quan với kết quả điều trị sớm lơ xê mi cấp dòng lympho trẻ em theo phác đồ FRALLE 2000 tại Viện Huyết học Truyền máu Trung ương giai đoạn 2016-2019. Tỷ lệ phát hiện bất thường NST thấp. Đột biến cấu trúc thường gặp hơn. Đột biến số lượng NST chủ yếu gặp trên lưỡng bội NST. Bước đầu thấy sự khác biệt về thời gian sống còn giữa các nhóm theo tiên lượng NSTCytogenetic variables in pediatric acute lymphoblastic leukemia (ALL) plays an important role inprognosis and risk grouping. Evaluation of early result treatment based on cytogenetic mutations providesdata for physicians in treatment options for pediatric patients.Objectives: Study on characteristics of chromosomal abnormalities and evaluate the relationship withthe early result of treatment according to FRALLE 2000 protocol at the National Institute of Hematology andBlood Transfusion.Subjects and research methods: This was a prospective study conducted on 188 pediatric ALLpatients who were treated at the National Institute of Hematology and Blood Transfusion from August 1,2016 to August 1, 2019.Results: The incidence of chromosomal abnormalities in pediatric ALL patients was 13.8%. Structuralabnormalities were more common (57.7% of structural abnormalities alone, 15.4% combined with structuraland numberal abnormalities, 26.9% of numberal abnormalities alone). The most common structuralabnormality was chromosomal translocations, in which t(9
22) was the most common. Hyperdiploidaccounted 90.9% in the abnormal number of chromosomes. The poor prognosis group accounted for ahigher proportion in the study. The good prognosis chromosome group had the best treatment results(Overal Survival - OS 12 months reached 100%, Event Free Survival - EFS 12 months reached 80.0 ±17.9%). The group with the poor prognosis of chromosome: OS 12 was only 66.0 ± 11.3%, EFS 49.4 ±12.2%. The difference was statistically significant with p <
0.01. The normal chromosome group had goodOS and EFS for 12 months, 90.4 ± 2.6% and 77.9 ± 3.6%, respectively.Conclusion: The rate of abnormalities chromosome was low. Structural mutations were more common.Hyperdiploid was mainly seen on numberal chromosome abnormalities. This study found the difference insurvival time between the groups according to the chromosome prognosis.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR