Introduction: Describe the results of analgesia care of incisional anesthesia with Anaropin 0.2% in combination with patient - controlled analgesia (PCA) after organ donor nephrectomy at Huu Nghi Viet Duc hospital in 2023. Methods: The study was conducted on 86 organ donor nephrectomy at Viet Duc hospital from February 2023 to August 2023. Although depending on the method of postoperative pain relief of the anesthesiologist, the research team put the patients into 2 groups. Group 1 consisted of 43 patients with indications for surgical anesthesia combined with PCA morphine, group 2 included 43 patients with indications for PCA morphine alone. Patients were monitored, collected data and assessed on VAS pain score, vital signs, unwanted effects, satisfaction within 24 hours after surgery. Results: The average VAS pain score of group 1 was lower than that of group 2 at the time of the study, the difference was statistically significant with p <
0.001. Pulse frequency, maximum blood pressure, and minimum blood pressure in the group. 1 was more stable than group 2 at the time of the study, with p <
0.001. The average amount of Morphine used of group 1 was lower than that of group 2 at the time of the study, the difference was statistically significant with p <
0.001. Median recovery time in group 1 was 16.75 ± 2.6 compared with group 2 was 19.15 ± 1.98. The difference in the two groups was statistically significant, with p <
0.001. The satisfaction of patients in group 1 was higher than in group 2. The difference in the two groups was statistically significant, with p <
0.001. Conclusion: The study showed that postoperative analgesia by anaropine infiltration anesthesia combined with PCA morphine had better analgesic effect, more stable vital signs, and patient satisfaction. higher than the group using PCA morphine alone, the difference was statistically significant with p <
0.05