Background: Hypertension is a common cardiovascular disease and has become a leading concern and the global prevalence of hypertension is increasing. Aldosterone / renin concentration is an important test to help diagnose and guide treatment of hypertension, especially in cases of resistant hypertension. This study aims to determine serum Renin concentration, serum Aldosterone concentration and Aldosterone / Renin ratio in hypertensive patients
and investigated the relationship, the correlation between Aldosterone / renin ratio and the severity of hypertension with some related factors in the study subjects. Methods: A cross - sectional descriptive study on 80 patients diagnosed with hypertension who visited the medical examination department, District 6 Hospital, HCMC from February 2019 to February 2020 from the age of 18 and older was quantified serum renin, serum aldosterone and aldosterone/renin ratio by ELISA method with enzyme - linked immunosorbent technique on automated immunoassay. Based on the quantitative results, analyze the relationship and correlation between serum Aldosterone/renin ratio with the severity of hypertension and some related factors (age and gender, SBP, BP, BMI, Sokolow Lyon index, ABI index, creatinine clearance coefficient and K+, Na+ concentrations). Results: The rate of hypertension stage I accounted for 40.0%
stage II was 38.8% and stage III was 12.5%. Overall Aldosterone concentration was 8.42 ± 5.04 µIU/ml
Aldosterone concentrations in 2 age groups (<
40 and ≥ 40 years old) were similar. Overall Renin concentration 34.07 ± 59.09 ng/dL
Median was 17.36. The Aldosterone / Renin ratio was 1.36 ± 3.54 µIU/ml/ng/dL
median was 0.41. Aldosterone / Renin ratio was positively correlated with age, Urea, Potassium (p <
0.05), Creatinine (p <
0.01) and negatively correlated with sodium (p <
0.05) and creatinine clearance (p). <
0.01). Aldosterone / Aldenin ratio was not correlated with Sokolov, BMI, ABI (p >
0.05). Aldosterone / Renin ROC curve in the prognosis of hypertension with a cut off of 0.26
AUC = 0.842 (95%CI = 0.744 - 0.914)
sensitivity 74% (95%CI = 62.4 - 83.5) and specificity 85.7% (95%CI = 42.1 - 99.6), the difference was statistically significant (p <
0.01). Conclusion: Quantification of Aldosterone / Renin ratio is beneficial for hypertensive subjects with suspected treatment resistance or risk prediction and screening for aldosterone resistance.