Research on factors affecting students’ intention to continue studying online at Tra Vinh University. Research on applying the technology acceptance model (TAM), successful information system model (ISS), and student satisfaction. Survey data from 312 students studying at the school are used. Structural Modeling (SEM) evaluates and validates the model. The results show that the quality of information, techniques - technology, interaction in the E-learning environment, perceived usefulness, lecturers, and learners themselves indirectly affect the intention to continue learning online through satisfaction. Management implications are also suggested, creating a basis for developing an E-learning system appropriate to the school and increasingstudents’ intention to continue learning online.